Publicaciones 2020

Masaracchia C, König A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohäker T, Lázaro DF, Zweckstetter M, Fernandez CO, Outeiro TF. Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies (2020) Biochim Biophys Acta Proteins Proteom 1868:140298. doi: 10.1016/j.bbapap.2019.140298.

Garro HA, Bruna-Haupt E, Cianchino V, Malizia F, Favier S, Menacho-Márquez M, Cifuente D, Fernández CO, Pungitore CR. Verbascoside, synthetic derivatives and other glycosides from Argentinian native plant species as potential antitumoral agents (2020) Nat Prod Res.10:1-6. doi: 10.1080/14786419.2019.1710701

Cukierman DS, Lázaro DF, Sacco P, Ferreira PR, Diniz R, Fernández CO, Outeiro TF, Rey NA.X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper(I)/copper(II)-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy. (2020) Dalton Trans. doi: 10.1039/d0dt01138j.

Palomino-Hernandez O, Buratti FA, Sacco PS, Rossetti G, Carloni P, Fernandez CO. Role of Tyr- 39 for the structural features of alpha-synuclein and for the interaction with a strong modulator of its amyloid assembly. (2020) Int. J. Mol. Sci., 21, 5061; doi:10.3390/ijms21145061

Publicaciones 2019

González N, Arcos-López T, König A, Quintanar L, Menacho Márquez M, Outeiro TF, Fernández CO. Effects of alpha-synuclein post-translational modifications on metal binding (2019) J Neurochem.150:507-521. doi: 10.1111/jnc.14721.

Rada JP, Bastos BSM, Anselmino L, Franco CHJ, Lanznaster M, Diniz R, Fernández CO, Menacho-Márquez M, Percebom AM, Rey NA. Binucleating Hydrazonic Ligands and Their μ-Hydroxodicopper(II) Complexes as Promising Structural Motifs for Enhanced Antitumor Activity. (2019) Inorg Chem. 58:8800-8819. doi: 10.1021/acs.inorgchem.9b01195.

González N, Gentile I, Garro HA, Delgado-Ocaña S, Ramunno CF, Buratti FA, Griesinger C, Fernández CO. Metal coordination and peripheral substitution modulate the activity of cyclic tetrapyrroles on αS aggregation: a structural and cell-based study (2019) J Biol Inorg Chem. 24:1269-1278. doi: 10.1007/s00775-019-01711-z.

Strohäker T, Jung BC, Liou SH, Fernandez CO, Riedel D, Becker S, Halliday GM, Bennati M, Kim WS, Lee SJ, Zweckstetter M. Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. (2019) Nat Commun. 10:5535. doi: 10.1038/s41467-019-13564-w.

Tonucci FM, Almada E, Borini-Etichetti C, Pariani A, Hidalgo F, Rico MJ, Girardini J, Favre C, Goldenring JR, Menacho-Marquez M, Larocca MC. Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis (2019) Cancer Lett. 461:65-77. doi: 10.1016/j.canlet.2019.07.006.

Borini Etichetti C, Di Benedetto C, Rossi C, Baglioni MV, Bicciato S, Del Sal G, Menacho-Marquez M, Girardini J. Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor (2019) J Biol Chem. 294:5060-5073. doi: 10.1074/jbc.RA118.006037

Publicaciones 2018

-Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO. Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.(2018) Biophys J. 114:1036-1045.

-Sánchez-López C, Fernández CO, Quintanar L. Neuroprotective alpha-cleavage of the human prion protein significantly impacts Cu(II) coordination at its His111 site. (2018) Dalton Trans. 47:9274-9282.

-Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF. Membrane binding, internalization, and sorting of alpha-synuclein in the cell. (2018) Acta Neuropathol Commun. 6:79.

-Cukierman DS, Accardo E, Gomes RG, De Falco A, Miotto MC, Freitas MCR, Lanznaster M, Fernández CO, Rey NA. Aroylhydrazones constitute a promising class of ‘metal-protein attenuating compounds’ for the treatment of Alzheimer’s disease: a proof-of-concept based on the study of the interactions between zinc(II) and pyridine-2-carboxaldehyde isonicotinoyl hydrazone. (2018) J Biol Inorg Chem. doi: 10.1007/s00775-018-1606-0

-Gentile I, Garro HA, Delgado Ocaña S, Gonzalez N, Strohäker T, Schibich D, Quintanar L, Sambrotta L, Zweckstetter M, Griesinger C, Menacho Márquez M, Fernández CO. Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features. (2018) Metallomics. doi: 10.1039/c8mt00232k.

-Priotti J, Baglioni MV, García A, Rico MJ, Leonardi D, Lamas MC, Menacho Márquez M. Repositioning of Anti-parasitic Drugs in Cyclodextrin Inclusion Complexes for Treatment of Triple-Negative Breast Cancer. AAPS PharmSciTech. 2018 Sep 25. doi: 10.1208/s12249-018-1169-y.

-Lorenzo-Martín LF, Citterio C, Menacho-Márquez M, Conde J, Larive RM, Rodríguez-Fdez S, García-Escudero R, Robles-Valero J, Cuadrado M, Fernández-Pisonero I, Dosil M, Sevilla MA, Montero MJ, Fernández-Salguero PM, Paramio JM, Bustelo XR. Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms. Oncogene. 2018 Aug 7. doi: 10.1038/s41388-018-0433-7.]

-Liceras-Boillos P, Jimeno D, García-Navas R, Lorenzo-Martín LF, Menacho-Marquez M, Segrelles C, Gómez C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Baltanás FC, Santos E. Differential role of the RasGEFs SOS1 and SOS2 in mouse skin homeostasis and carcinogenesis. Mol Cell Biol. 2018 May 29. pii: MCB.00049-18. doi: 10.1128/MCB.00049-18.

Publicaciones 2017

-González-Lizárraga F, Socías SB, Ávila CL, Torres-Bugeau CM, Barbosa LR, Binolfi A, Sepúlveda-Díaz JE, Del-Bel E, Fernandez CO, Papy-Garcia D, Itri R, Raisman-Vozari R, Chehín RN. Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species. (2017) Sci Rep. 7:41755.

-Cukierman DS, Pinheiro AB, Castiñeiras-Filho SL, da Silva AS, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha AL, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, Rey NA. A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson’s disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies. (2017) J Inorg Biochem. 170:160-168.

-Villar-Piqué A, Rossetti G, Ventura S, Carloni P, Fernández CO, Outeiro TF Copper(II) and the pathological H50Q α-synuclein mutant: Environment meets genetics. (2017) Commun Integr Biol. 10:e1270484.

-Fonseca-Ornelas L, Schmidt C, Camacho-Zarco AR, Fernandez CO, Becker S, Zweckstetter M. Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure.(2017) Chemistry 23:13010-13014.

-Miotto MC, Pavese MD, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO. Bioinorganic Chemistry of Parkinson’s Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.(2017) Inorg Chem. 56:10387-10395.

-Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2017 Nov 13;32(5):608-623.e9. doi:0.1016/j.ccell.2017.10.004.

-Rico M, Baglioni M, Bondarenko M, Laluce NC, Rozados V, André N, Carré M, Scharovsky OG, Menacho Márquez M. Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models. Oncotarget. 2017 Jan 10;8(2):2874-2889. doi: 10.18632/oncotarget.13760.

Publicaciones 2016

-Rossetti G, Musiani F, Abad E, Dibenedetto D, Mouhib H, Fernandez CO, Carloni P Conformational ensemble of human α-synuclein physiological form predicted by molecular simulations (2016) Phys Chem Chem Phys, 18:5702-5706.

-Arcos-López T, Qayyum M, Rivillas-Acevedo L, Miotto MC, Grande-Aztatzi R, Fernández CO, Hedman B, Hodgson KO, Vela A, Solomon EI, Quintanar L. Spectroscopic and Theoretical Study of Cu(I) Binding to His111 in the Human Prion Protein Fragment 106-115 (2016) Inorg Chem 55:2909-2922.

-Valiente-Gabioud AA, Miotto MC, Chesta ME, Lombardo V, Binolfi A, Fernandez CO. Phthalocyanines as molecular scaffolds to block disease-associated protein aggregation (2016) Acc Chem Res 49:801-808.

-Rodríguez EE, Arcos-López T, Trujano-Ortiz LG, Fernández CO, González FJ, Vela A, Quintanar L. Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein (2016) J Biol Inorg Chem. 21:691-702.

-Sánchez-López C, Cortés-Mejía R, Miotto MC, Binolfi A, Fernández CO, Del Campo JM, Quintanar L. Copper Coordination Features of Human Islet Amyloid Polypeptide: The Type 2 Diabetes Peptide. (2016) Inorg Chem

-Villar-Piqué A, Lopes da Fonseca T, Sant’Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. (2016) Proc Natl Acad Sci U S A. 113:E6506-E6515.

-Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig PA, Prazeres da Costa C, Vanes L, Kumar V, Johnson M, Menacho-Márquez M, Habermann B, Tybulewicz VL, Netea M, Bustelo XR, Ruland J. Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity. Cell Rep. 2016 Dec 6;17(10):2572-2583. doi: 10.1016/j.celrep.2016.11.018.